Article
Homozygously deleted gene DACH1 regulates tumor-initiating activity of glioma cells.
Proceedings of the National Academy of Sciences of the United States of America - 26 Jul 2011
Watanabe Akira, Ogiwara Hideki, Ehata Shogo, Mukasa Akitake, Ishikawa Shumpei, Maeda Daichi, Ueki Keisuke, Ino Yasushi, Todo Tomoki, Yamada Yasuhiro, Fukayama Masashi, Saito Nobuhito, Miyazono Kohei, Aburatani Hiroyuki
Abstract excerpt
Loss or reduction in function of tumor suppressor genes contributes to tumorigenesis. Here, by allelic DNA copy number analysis using single-nucleotide polymorphism genotyping array and mass spectrometry, we report homozygous deletion in glioblastoma multiformes at chromosome 13q21, where DACH1 gene is located. We found decreased cell proliferation of a series of glioma cell lines by forced expression of DACH1....
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