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Article

Ski overexpression in skeletal muscle modulates genetic programs that control susceptibility to diet-induced obesity and insulin signaling.

Obesity (Silver Spring, Md.) - 1 Nov 2012

Diaz Marianne, Martel Nick, Fitzsimmons Rebecca L, Eriksson Natalie A, Cowin Gary J, Thomas Gethin P, Cao Kim-Anh Lê, Muscat George E O, Leong Gary M

Abstract excerpt

Transgenic mice overexpressing chicken Ski (c-Ski) have marked decrease in adipose mass with skeletal muscle hypertrophy. Recent evidence indicates a role for c-Ski in lipogenesis and energy expenditure. In the present study, wild type (WT) and c-Ski mice were challenged on a high-fat (HF) diet to determine whether c-Ski mice were resistant to diet-induced obesity. During the HF feeding WT mice gained...

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PMID: 22513493
DOI: 10.1038/oby.2012.101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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