Article

AKT2 deficiency causes sarcopenia and metabolic disorder of skeletal muscle

2019-10-16

Abstract excerpt

Skeletal muscle is responsible for the majority of glucose disposal in the body. Insulin resistance in the skeletal muscle accounts for 85-90% of the impairment of total body glucose disposal in patients with tye 2 diabetes (T2D). However, the mechanism remains controversial. AKT2 is a protein kinase performing important functions in the regulation of glucose metabolism. We observed that mice deficient for AKT2 (...

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Literature Corpus work: 8983c816-9307-572a-9dca-cdd160c26286
DOI: 10.1101/805812

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