Article
High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila.
Cell metabolism - 3 Nov 2010
Birse Ryan T, Choi Joan, Reardon Kathryn, Rodriguez Jessica, Graham Suzanne, Diop Soda, Ocorr Karen, Bodmer Rolf, Oldham Sean
Abstract excerpt
High-fat-diet (HFD)-induced obesity is a major contributor to diabetes and cardiovascular disease, but the underlying genetic mechanisms are poorly understood. Here, we use Drosophila to test the hypothesis that HFD-induced obesity and associated cardiac complications have early evolutionary origins involving nutrient-sensing signal transduction pathways. We find that HFD-fed flies exhibit increased triglyceride...
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