Article
Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies.
Nature communications - 25 Apr 2018
Boyd Mette, Thodberg Malte, Vitezic Morana, Bornholdt Jette, Vitting-Seerup Kristoffer, Chen Yun, Coskun Mehmet, Li Yuan, Lo Bobby Zhao Sheng, Klausen Pia, Jan Schweiger Pawel, Pedersen Anders Gorm, Rapin Nicolas, Skovgaard Kerstin, Dahlgaard Katja, Andersson Robin, Terkelsen Thilde Bagger, Lilje Berit, Troelsen Jesper Thorvald, Petersen Andreas Munk, Jensen Kim Bak, Gögenur Ismail, Thielsen Peter, Seidelin Jakob Benedict, Nielsen Ole Haagen, Bjerrum Jacob Tveiten, Sandelin Albin
Abstract excerpt
Inflammatory bowel disease (IBD) is a chronic intestinal disorder, with two main types: Crohn's disease (CD) and ulcerative colitis (UC), whose molecular pathology is not well understood. The majority of IBD-associated SNPs are located in non-coding regions and are hard to characterize since regulatory regions in IBD are not known. Here we profile transcription start sites (TSSs) and enhancers in the descending...
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