Article
ASTN1 and alcohol dependence: family-based association analysis in multiplex alcohol dependence families.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jun 2012
Hill Shirley Y, Weeks Daniel E, Jones Bobby L, Zezza Nicholas, Stiffler Scott
Abstract excerpt
A previous genome-wide linkage study of alcohol dependence (AD) in multiplex families found a suggestive linkage result for a region on Chromosome 1 near microsatellite markers D1S196 and D1S2878. The ASTN1 gene is in this region, a gene previously reported to be associated with substance abuse, bipolar disorder and schizophrenia. Using the same family data consisting of 330 individuals with phenotypic data and...
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