Article
A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53.
Molecular psychiatry - 1 Nov 2013
Wang J-C, Foroud T, Hinrichs A L, Le N X H, Bertelsen S, Budde J P, Harari O, Koller D L, Wetherill L, Agrawal A, Almasy L, Brooks A I, Bucholz K, Dick D, Hesselbrock V, Johnson E O, Kang S, Kapoor M, Kramer J, Kuperman S, Madden P A F, Manz N, Martin N G, McClintick J N, Montgomery G W, Nurnberger J I, Rangaswamy M, Rice J, Schuckit M, Tischfield J A, Whitfield J B, Xuei X, Porjesz B, Heath A C, Edenberg H J, Bierut L J, Goate A M
Abstract excerpt
Several studies have identified genes associated with alcohol-use disorders (AUDs), but the variation in each of these genes explains only a small portion of the genetic vulnerability. The goal of the present study was to perform a genome-wide association study (GWAS) in extended families from the Collaborative Study on the Genetics of Alcoholism to identify novel genes affecting risk for alcohol dependence (AD)....
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