Article
Family-based association analysis of alcohol dependence criteria and severity.
Alcoholism, clinical and experimental research - 1 Feb 2014
Wetherill Leah, Kapoor Manav, Agrawal Arpana, Bucholz Kathleen, Koller Daniel, Bertelsen Sarah E, Le Nhung, Wang Jen-Chyong, Almasy Laura, Hesselbrock Victor, Kramer John, Nurnberger John I, Schuckit Marc, Tischfield Jay A, Xuei Xiaoling, Porjesz Bernice, Edenberg Howard J, Goate Alison M, Foroud Tatiana
Abstract excerpt
BACKGROUND: Despite the high heritability of alcohol dependence (AD), the genes found to be associated with it account for only a small proportion of its total variability. The goal of this study was to identify and analyze phenotypes based on homogeneous classes of individuals to increase the power to detect genetic risk factors contributing to the risk of AD. METHODS: The 7 individual DSM-IV criteria for AD...
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