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Article

Loss of Urate Oxidase Activity in Hominoids and its Evolutionary Implications

1 May 2002

Abstract excerpt

We have determined and compared the promoter, coding, and intronic sequences of the urate oxidase (Uox) gene of various primate species. Although we confirm the previous observation that the inactivation of the gene in the clade of the human and the great apes results from a single CGA to TGA nonsense mutation in exon 2, we find that the inactivation in the gibbon lineage results from an independent nonsense...

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PMID: 11961098
DOI: 10.1093/oxfordjournals.molbev.a004123

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