Article

Cysteine enrichment mediates co-option of uricase in reptilian skin and transition to uricotelism

2023-06-05

Abstract excerpt

Uric acid is the main means of nitrogen excretion in uricotelic vertebrates (birds and reptiles) and the end product of purine catabolism in humans and a few other mammals. While uricase is inactivated in mammals unable to degrade urate, the presence of orthologous genes without inactivating mutations in avian and reptilian genomes is unexplained. Here we show that the Gallus gallus gene we name cysteine-rich ura...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a4fcf036-30e1-54ed-b99f-fb2d3541ead8
DOI: 10.1101/2023.06.02.543418

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cysteine enrichment mediates co-option of uricase in reptilian skin and transition to uricotelismDOI 10.1101/2023.06.02.543418Read

A widely distributed gene cluster compensates for uricase loss in hominidsSemantic proximity Read

Catalysis and Structure of Zebrafish Urate Oxidase Provide Insights into the Origin of Hyperuricemia in HominoidsSemantic proximity Read

Conservation of a Chromosome 8 Inversion and Exon Mutations Confirm Common Gulonolactone Oxidase Gene Evolution Among Primates, Including H. Neanderthalensis.Semantic proximity Read

Structure-based characterization of canine-human chimeric uricases and its evolutionary implications.Semantic proximity Read

The identification of an integral membrane, cytochrome c urate oxidase completes the catalytic repertoire of a therapeutic enzyme.Semantic proximity Read

Engineering Human Urate Oxidase: Towards Reactivating It as an Important Therapeutic Enzyme.Semantic proximity Read

Uric acid: a danger signal from the RNA world that may have a role in the epidemic of obesity, metabolic syndrome, and cardiorenal disease: evolutionary considerations.Semantic proximity Read

Gains, Losses and Changes of Function after Gene Duplication: Study of the Metallothionein FamilySemantic proximity Read

The evolutionary fate of the genes encoding the purine catabolic enzymes in hominoids, birds, and reptiles.Semantic proximity Read

Linkage analysis with an interbreed backcross maps Dalmatian hyperuricosuria to CFA03.Semantic proximity Read

Metabolic and chaperone gene loss marks the origin of animals: evidence for Hsp104 and Hsp78 chaperones sharing mitochondrial enzymes as clients.Semantic proximity Read

Uric acid nephrolithiasis: proton titration of an essential molecule?Semantic proximity Read