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Article

Uric acid nephrolithiasis: proton titration of an essential molecule?

Current opinion in nephrology and hypertension - 1 Jul 2006

Moe Orson W

Abstract excerpt

PURPOSE OF REVIEW: The majority of uric acid nephrolithiasis in humans occurs in the absence of frank hyperuricosuria and is primarily a disease of excessively low urinary pH. Uric acid is substantially less soluble than urate salts so in low urine pH urate is protonated, thus favoring precipitation even under what is considered physiologic concentrations of total urinary uric acid/urate. This commentary examines...

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PMID: 16775450
DOI: 10.1097/01.mnh.0000232876.04975.33

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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