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Article

A variant of the neuronal amino acid transporter SLC6A15 is associated with ACTH and cortisol responses and cognitive performance in unipolar depression.

The international journal of neuropsychopharmacology - 1 Feb 2013

Schuhmacher Anna, Lennertz Leonhard, Wagner Michael, Höfels Susanne, Pfeiffer Ute, Guttenthaler Vera, Maier Wolfgang, Zobel Astrid, Mössner Rainald

Abstract excerpt

Major depressive disorder (MDD) is accompanied by both cognitive impairments and a hyperactivity of the hypothalamic-pituitary-adrenocortical (HPA) system, resulting in an enhanced glucocorticoid secretion. Cortisol acts via mineralocorticoid and glucocorticoid receptors densely located in the hippocampus, a brain area that is important regarding cognitive functions and especially memory functions. Recently, a...

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PMID: 22475622
DOI: 10.1017/S1461145712000223

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CRH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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