Modulation of cortisol responses to the DEX/CRH test by polymorphisms of the interleukin-1beta gene in healthy adults.

doi:10.1186/1744-9081-7-23

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Modulation of cortisol responses to the DEX/CRH test by polymorphisms of the interleukin-1beta gene in healthy adults.

Behavioral and brain functions : BBF - 5 Jul 2011

Sasayama Daimei, Hori Hiroaki, Iijima Yoshimi, Teraishi Toshiya, Hattori Kotaro, Ota Miho, Fujii Takashi, Higuchi Teruhiko, Amano Naoji, Kunugi Hiroshi

Abstract excerpt

BACKGROUND: Recently, hypothalamus-pituitary-adrenal (HPA) axis function assessed with the combined dexamethasone (DEX)/corticotropin releasing hormone (CRH) test has been shown to be associated with response to antidepressant treatment. A polymorphism (rs16944) in the interleukin-1beta (IL-1β) gene has also been reported to be associated with the medication response in depression. These findings prompted us to...

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PMID: 21726461
DOI: 10.1186/1744-9081-7-23
PMCID: PMC3141407

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