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Article

Polymorphisms within the metabotropic glutamate receptor 1 gene are associated with depression phenotypes.

Psychoneuroendocrinology - 1 Apr 2012

Menke Andreas, Sämann Philipp, Kloiber Stefan, Czamara Darina, Lucae Susanne, Hennings Johannes, Heck Angela, Kohli Martin A, Czisch Michael, Müller-Myhsok Bertram, Holsboer Florian, Binder Elisabeth B

Abstract excerpt

OBJECTIVES: Glutamate has been implicated in the pathophysiology and treatment of mood disorders possibly by affecting the regulation of the hypothalamus-pituitary-adrenocortical (HPA) axis. Growing evidence suggests an important role of the metabotropic glutamate receptor 1 (mGlu1) in depression-related phenotypes. To test whether these findings can also be supported by human genetics data, we explored...

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Source

Identifiers

PMID: 21962378
DOI: 10.1016/j.psyneuen.2011.09.003

Genes

GRM1
CRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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