Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional coding variants in SLC6A15, a possible risk gene for major depression.

PloS one - 1 Jan 2013

Quast Carina, Cuboni Serena, Bader Daniel, Altmann André, Weber Peter, Arloth Janine, Röh Simone, Brückl Tanja, Ising Marcus, Kopczak Anna, Erhardt Angelika, Hausch Felix, Lucae Susanne, Binder Elisabeth B

Abstract excerpt

SLC6A15 is a neuron-specific neutral amino acid transporter that belongs to the solute carrier 6 gene family. This gene family is responsible for presynaptic re-uptake of the majority of neurotransmitters. Convergent data from human studies, animal models and pharmacological investigations suggest a possible role of SLC6A15 in major depressive disorder. In this work, we explored potential functional variants in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Depressive Disorder, Major

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Genetic Predisposition to Disease

Share to Genotype

Share to Polymorphism, Single Nucleotide

Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

Source

Open in PubMed Open full text

Identifiers

PMID: 23874702
DOI: 10.1371/journal.pone.0068645
PMCID: PMC3712998

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional coding variants in SLC6A15, a possible risk gene for major depression.PMID 23874702Read ↗

The neuronal transporter gene SLC6A15 confers risk to major depression.Semantic proximity Read ↗

SLC6A15, a novel stress vulnerability candidate, modulates anxiety and depressive-like behavior: involvement of the glutamatergic system.Semantic proximity Read ↗

Identification of SLC25A37 as a major depressive disorder risk gene.Semantic proximity Read ↗

Association Study of the SLC1A2 (rs4354668), SLC6A9 (rs2486001) and SLC6A5 (rs2000959) Polymorphisms in Major Depressive DisorderSemantic proximity Read ↗

Effects of a Polymorphism of the Neuronal Amino Acid Transporter SLC6A15 Gene on Structural Integrity of White Matter Tracts in Major Depressive Disorder.Semantic proximity Read ↗

The interplay between SLC6A4 and HTR1A genetic variants that may lead to antidepressant failure.Semantic proximity Read ↗

Association Study of the SLC1A2 (rs4354668), SLC6A9 (rs2486001), and SLC6A5 (rs2000959) Polymorphisms in Major Depressive DisorderSemantic proximity Read ↗

Common variants in SLC6A2, SLC6A3, DRD2, and major depressive disorder: an association study in the Chinese Han population.Semantic proximity Read ↗

Genetic and functional studies of a missense variant in a glutamate transporter, SLC1A3, in Tourette syndrome.Semantic proximity Read ↗

Genetic variants in the vesicular monoamine transporter 1 (VMAT1/SLC18A1) and neuropsychiatric disorders.Semantic proximity Read ↗

Association of major depression with rare functional variants in norepinephrine transporter and serotonin1A receptor genes.Semantic proximity Read ↗

A variant of the neuronal amino acid transporter SLC6A15 is associated with ACTH and cortisol responses and cognitive performance in unipolar depression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.