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Article

Impact of gene-gender effects of adrenergic polymorphisms on hypothalamic-pituitary-adrenal axis activity in depressed patients.

Neuropsychobiology - 1 Jan 2008

Haefner S, Baghai T C, Schule C, Eser D, Spraul M, Zill P, Rupprecht R, Bondy B

Abstract excerpt

OBJECTIVE: There is overwhelming evidence that activation of the hypothalamic-pituitary-adrenal (HPA) system plays a major role in depression and cardiovascular disease in genetically susceptible individuals. We hypothesized that due to the multiple interactions between the sympathetic and the HPA systems via adrenoceptors, polymorphisms in these genes could have an impact on HPA axis activity in major...

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Share to Adrenocorticotropic Hormone
Share to Depressive Disorder, Major

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hypothalamo-Hypophyseal System

Share to Pituitary-Adrenal System

Share to Receptors, Adrenergic, alpha-2

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Source

Identifiers

PMID: 19088492
DOI: 10.1159/000182891

Genes

ADRB2
CRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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