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Article

Elimination of shelterin components bypasses RNAi for pericentric heterochromatin assembly.

Genes & development - 15 Nov 2013

Tadeo Xavier, Wang Jiyong, Kallgren Scott P, Liu Jinqiang, Reddy Bharat D, Qiao Feng, Jia Songtao

Abstract excerpt

The RNAi pathway is required for heterochromatin assembly at repetitive DNA elements in diverse organisms. In fission yeast, loss of RNAi causes pericentric heterochromatin defects, compromising gene silencing and chromosome segregation. Here we show that deletion of telomere shelterin components restores pericentric heterochromatin and its functions in RNAi mutants. We further isolated a separation-of-function...

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Share to Chromatin Assembly and Disassembly
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Mutation

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Source

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Identifiers

PMID: 24240238
DOI: 10.1101/gad.226118.113
PMCID: PMC3841737

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Elimination of shelterin components bypasses RNAi for pericentric heterochromatin assembly.PMID 24240238Read ↗

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Interaction of APC/C-E3 ligase with Swi6/HP1 and Clr4/Suv39 in heterochromatin assembly in fission yeast.Semantic proximity Read ↗

Rapid epigenetic adaptation to uncontrolled heterochromatin spreading.Semantic proximity Read ↗

Spt6 is required for heterochromatic silencing in the fission yeast Schizosaccharomyces pombe.Semantic proximity Read ↗

The chromodomain protein Swi6: a key component at fission yeast centromeres.Semantic proximity Read ↗

RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production.Semantic proximity Read ↗

The INO80 Complex Regulates Epigenetic Inheritance of Heterochromatin.Semantic proximity Read ↗

The proper connection between shelterin components is required for telomeric heterochromatin assembly.Semantic proximity Read ↗

Heterochromatin protein 1 homologue Swi6 acts in concert with Ers1 to regulate RNAi-directed heterochromatin assembly.Semantic proximity Read ↗

Histone variant H2A.Z regulates centromere silencing and chromosome segregation in fission yeast.Semantic proximity Read ↗

RNAi-dependent formation of heterochromatin and its diverse functions.Semantic proximity Read ↗

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