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Article

Coupling of double-stranded RNA synthesis and siRNA generation in fission yeast RNAi.

Molecular cell - 3 Aug 2007

Colmenares Serafin U, Buker Shane M, Buhler Marc, Dlakić Mensur, Moazed Danesh

Abstract excerpt

The fission yeast centromeric repeats are transcribed and ultimately processed into small interfering RNAs (siRNAs) that are required for heterochromatin formation. siRNA generation requires dsRNA synthesis by the RNA-directed RNA polymerase complex (RDRC) and processing by the Dicer ribonuclease. Here we show that Dcr1, the fission yeast Dicer, is physically associated with RDRC. Dcr1 generates siRNAs in an...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 17658285
DOI: 10.1016/j.molcel.2007.07.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Coupling of double-stranded RNA synthesis and siRNA generation in fission yeast RNAi.PMID 17658285Read ↗

RNA-dependent RNA polymerase is an essential component of a self-enforcing loop coupling heterochromatin assembly to siRNA production.Semantic proximity Read ↗

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Raf1 Is a DCAF for the Rik1 DDB1-like protein and has separable roles in siRNA generation and chromatin modification.Semantic proximity Read ↗

Splicing factors facilitate RNAi-directed silencing in fission yeast.Semantic proximity Read ↗

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