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Article

C/EBPα and DEK coordinately regulate myeloid differentiation

4 Apr 2012

Abstract excerpt

The transcription factor C/EBPα is a critical mediator of myeloid differentiation and is often functionally impaired in acute myeloid leukemia. Recent studies have suggested that oncogenic FLT3 activity disrupts wild-type C/EBPα function via phosphorylation on serine 21 (S21). Despite the apparent role of pS21 as a negative regulator of C/EBPα transcription activity, the mechanism by which phosphorylation tips...

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PMID: 22474248
DOI: 10.1182/blood-2011-10-383083

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