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Article

Elephant TP53-RETROGENE 9 induces transcription-independent apoptosis at the mitochondria

16 Feb 2023

Abstract excerpt

Approximately 20 TP53 retrogenes exist in the African and Asian elephant genomes (Loxodonta Africana, Elephas Maximus) in addition to a conserved TP53 gene that encodes a full-length protein. Elephant TP53-RETROGENE 9 (TP53-R9) encodes a p53 protein (p53-R9) that is truncated in the middle of the canonical DNA binding domain. This C-terminally truncated p53 retrogene protein lacks the nuclear localization signals...

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PMID: 36797268
DOI: 10.1038/s41420-023-01348-7

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