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Article

DRAM-1 encodes multiple isoforms that regulate autophagy

1 Jan 2012

Abstract excerpt

Macro(autophagy) is a cellular mechanism which delivers cytoplasmic constituents to lysosomes for degradation. Due to its role in maintaining cellular integrity, autophagy protects against various diseases including cancer. p53 is a major tumor suppressor gene which can modulate autophagy both positively and negatively. p53 induces autophagy via transcriptional activation of Damage-Regulated Autophagy Modulator...

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PMID: 22082963
DOI: 10.4161/auto.8.1.18077

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