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Article

Analysis of DRAM-related proteins reveals evolutionarily conserved and divergent roles in the control of autophagy

15 Jul 2009

Abstract excerpt

Autophagy is a membrane-trafficking process that serves to deliver cytoplasmic proteins and organelles to the lysosome for degradation. The process is genetically defined and many of the factors involved are conserved from yeast to man. Recently, a number of new autophagy regulators have been defined, including the Damage-Regulated Autophagy Modulator (DRAM), which is a lysosomal protein that links autophagy and...

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PMID: 19556885
DOI: 10.4161/cc.8.14.9050

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