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Article

TP53INP2 contributes to autophagosome formation by promoting LC3-ATG7 interaction

15 Feb 2019

Abstract excerpt

TP53INP2/DOR (tumor protein p53-inducible nuclear protein 2) contributes to mammalian macroautophagy/autophagy by carrying nuclear deacetylated MAP1LC3/LC3 to the cytoplasm. Here, we report that in the cytoplasm, TP53INP2 further functions in autophagosome biogenesis by promoting LC3B-ATG7 interaction. Cytoplasmic expression of the N-terminal region of TP53INP2, which includes the LC3-interacting region,...

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Identifiers

PMID: 30767704
DOI: 10.1080/15548627.2019.1580510

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