Article
TRAF3 alterations are frequent in del-3'IGH chronic lymphocytic leukemia patients and define a specific subgroup with adverse clinical features.
American journal of hematology - 1 Jul 2022
Pérez-Carretero Claudia, Hernández-Sánchez María, González Teresa, Quijada-Álamo Miguel, Martín-Izquierdo Marta, Santos-Mínguez Sandra, Miguel-García Cristina, Vidal María-Jesús, García-De-Coca Alfonso, Galende Josefina, Pardal Emilia, Aguilar Carlos, Vargas-Pabón Manuel, Dávila Julio, Gascón-Y-Marín Isabel, Hernández-Rivas José-Ángel, Benito Rocío, Hernández-Rivas Jesús-María, Rodríguez-Vicente Ana-Eugenia
Abstract excerpt
Interstitial 14q32 deletions involving IGH gene are infrequent events in chronic lymphocytic leukemia (CLL), affecting less than 5% of patients. To date, little is known about their clinical impact and molecular underpinnings, and its mutational landscape is currently unknown. In this work, a total of 871 CLLs were tested for the IGH break-apart probe, and 54 (6.2%) had a 300 kb deletion of 3'IGH (del-3'IGH...
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