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Article

Desensitization and internalization of the m2 muscarinic acetylcholine receptor are directed by independent mechanisms.

The Journal of biological chemistry - 1 Dec 1995

Pals-Rylaarsdam R, Xu Y, Witt-Enderby P, Benovic J L, Hosey M M

Abstract excerpt

The phenomenon of acute desensitization of G-protein-coupled receptors has been associated with several events, including receptor phosphorylation, loss of high affinity agonist binding, receptor:G-protein uncoupling, and receptor internalization. However, the biochemical events underlying these processes are not fully understood, and their contributions to the loss of signaling remain correlative. In addition,...

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Identifiers

PMID: 7499433
DOI: 10.1074/jbc.270.48.29004

Genes

GRK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Desensitization and internalization of the m2 muscarinic acetylcholine receptor are directed by independent mechanisms.PMID 7499433Read ↗

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