Article
Desensitization and internalization of the m2 muscarinic acetylcholine receptor are directed by independent mechanisms.
The Journal of biological chemistry - 1 Dec 1995
Pals-Rylaarsdam R, Xu Y, Witt-Enderby P, Benovic J L, Hosey M M
Abstract excerpt
The phenomenon of acute desensitization of G-protein-coupled receptors has been associated with several events, including receptor phosphorylation, loss of high affinity agonist binding, receptor:G-protein uncoupling, and receptor internalization. However, the biochemical events underlying these...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Biological Transport
- Cell Line
- Cyclic AMP-Dependent Protein Kinases
- DNA Primers
- Genes, Dominant
- Humans
- Molecular Sequence Data
- Mutagenesis
- Phosphorylation
- Receptors, Muscarinic
- Sequence Deletion
- beta-Adrenergic Receptor Kinases