Article
CYP2C19 and PON1 polymorphisms regulating clopidogrel bioactivation in Chinese, Malay and Indian subjects.
Pharmacogenomics - 1 Apr 2012
Chan Mark Y, Tan Karen, Tan Huay-Cheem, Huan Pei-Tee, Li Bei, Phua Qian-Hui, Lee Hong-Kai, Lee Chi-Hang, Low Adrian, Becker Richard C, Ong Wen-Chong, Richards Mark A, Salim Agus, Tai E-Shyong, Koay Evelyn
Abstract excerpt
UNLABELLED: AIM, MATERIALS & METHODS: We investigated the functional significance of CYP2C19*2, *3, *17 and PON1 Q192R SNPs in 89 consecutive Asian patients on clopidogrel treatment and the prevalence of functionally significant polymorphisms among 300 Chinese, Malays and Asian Indians. RESULTS: Both CYP2C19 loss-of-function alleles (*2 or *3) were associated with higher platelet reactivity while the CYP2C19...
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