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Article

Genetic determinants of high on-treatment platelet reactivity in clopidogrel treated Chinese patients.

Thrombosis research - 1 Jul 2013

Zhang Lanning, Chen Yanming, Jin Ying, Qu Fei, Li Jiayue, Ma Cong, Yang Jie, Xu Bin, Wang Hongjuan, Li Xiaoqi, Li Yang, Zhang Yuxiao, Lu Caiyi, Yin Tong

Abstract excerpt

INTRODUCTION: Cytochrome P450 (CYP), ATP-binding cassette transporters (ABCB1), and paraoxonase-1 (PON1) play crucial roles in clopidogel absorption and bioactivation. Genetic polymorphisms in these genes have been associated with the variability of the response to clopidogrel, however their contribution to high on-treatment platelet reactivity (HPR) in clopidogrel treated Chinese patients is less known....

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Identifiers

PMID: 23726091
DOI: 10.1016/j.thromres.2013.05.006

Genes

HPR
ABCB1
PON1

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