Article
CYP2C19 genotypes and their impact on clopidogrel responsiveness in percutaneous coronary intervention.
International journal of clinical pharmacy - 1 Aug 2013
Mejin Melissa, Tiong Wen Ni, Lai Lana Yin Hui, Tiong Lee Len, Bujang Adam Mohamad, Hwang Siaw San, Ong Tiong Kiam, Fong Alan Yean Yip
Abstract excerpt
BACKGROUND: Cytochrome P450 2C19 (CYP2C19) loss-of-function polymorphisms are more common in Asian populations and have been associated with diminished antiplatelet response to clopidogrel. In this era of 'personalised medicine', combining genotyping and phenotyping as a strategy to personalise antiplatelet therapy warrants further exploration. OBJECTIVE: This study aimed to investigate the prevalence and impact...
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