Article
Genetic determinants of clopidogrel responsiveness in Koreans treated with drug-eluting stents.
International journal of cardiology - 10 Feb 2013
Park Jin Joo, Park Kyung Woo, Kang Jeehoon, Jeon Ki-Hyun, Kang Si-Hyuck, Ahn Hyo Suk, Han Jung-Kyu, Koh Jin-Sin, Lee Sang Eun, Yang Han-Mo, Lee Hae-Young, Kang Hyun-Jae, Koo Bon-Kwon, Oh Byung-Hee, Park Young-Bae, Kim Hyo-Soo
Abstract excerpt
BACKGROUND: Variations of genes encoding cytochrome enzymes, drug transporters, and paraoxonase have recently been reported to be associated with clopidogrel response variability besides the well-known CYP2C19 loss-of-function (LOF) alleles. We determined whether newly reported genetic variations are associated with clopidogrel on-treatment platelet reactivity (OPR) in Korean patients. METHODS: OPR was measured...
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