PON1 Q192R is associated with high platelet reactivity with clopidogrel in patients undergoing elective neurointervention: A prospective single-center cohort study.

doi:10.1371/journal.pone.0254067

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Article

PON1 Q192R is associated with high platelet reactivity with clopidogrel in patients undergoing elective neurointervention: A prospective single-center cohort study.

PloS one - 1 Jan 2021

Tanaka Koji, Matsumoto Shoji, Ainiding Gulibahaer, Nakahara Ichiro, Nishi Hidehisa, Hashimoto Tetsuya, Ohta Tsuyoshi, Sadamasa Nobutake, Ishibashi Ryota, Gomi Masanori, Saka Makoto, Miyata Haruka, Watanabe Sadayoshi, Okata Takuya, Sonoda Kazutaka, Koge Junpei, Iinuma Kyoko M, Furuta Konosuke, Nagata Izumi, Matsuo Keitaro, Matsushita Takuya, Isobe Noriko, Yamasaki Ryo, Kira Jun-Ichi

Abstract excerpt

BACKGROUND AND PURPOSE: The impact of the paraoxonase-1 (PON1) polymorphism, Q192R, on platelet inhibition in response to clopidogrel remains controversial. We aimed to investigate the association between carrier status of PON1 Q192R and high platelet reactivity (HPR) with clopidogrel in patients undergoing elective neurointervention. METHODS: Post-clopidogrel platelet reactivity was measured using a VerifyNow®...

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PMID: 34351918
DOI: 10.1371/journal.pone.0254067
PMCID: PMC8341610

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Source receipt: pubmed, retrieved 7 Sept 2026.

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