Article
PON1 Q192R genotype influences clopidogrel responsiveness by relative platelet inhibition instead of on-treatment platelet reactivity.
Thrombosis research - 1 Oct 2013
Li Xiaoqi, Zhang Lanning, Chen Xi, Qu Fei, Li Jiayue, Ma Cong, Yang Jie, Xu Bin, Wang Hongjuan, Xu Qiang, Zhang Yuxiao, Li Yang, Lu Caiyi, Yin Tong
Abstract excerpt
BACKGROUND: paraoxonase-1 (PON1) was recently identified as the crucial enzyme for clopidogrel bioactivation, with PON1 Q192R (rs662) polymorphism determining the clopidogel antiplatelet efficacy. However, subsequent studies showed controversies over the findings. This study aimed to evaluate the impact of PON1 Q192R in parallel to that of CYP2C19*2 (rs4244285) on clopidogrel responsiveness in a cohort of Chinese...
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