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Article

Pharmacogenomic evaluation of CYP2C19 alleles linking low clopidogrel response and the risk of acute coronary syndrome in Indians.

The journal of gene medicine - 1 Jan 2024

Bhat Keshavamurthy Ganapathy, Pillai Ratheesh Kumar Janardhana, Lodhi Heemanshu, Guleria Vivek Singh, Abbot Anil Kumar, Gupta Love, Rastogi Garima, Sharma Anuka, Mohammed Zafar, Sharma Varun

Abstract excerpt

BACKGROUND: Clopidogrel is an antiplatelet drug widely prescribed to prevent atherothrombotic events in coronary artery disease patients. However, there is evidence to suggest that the effectiveness of clopidogrel varies owing to genetic diversity in CYP2C19. This heterogeneity in South Asians, who are also known to have high risk of cardiac events than other population groups, highlights the importance of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37985132
DOI: 10.1002/jgm.3634

Genes

CYP2C19

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