Article
Power comparison of admixture mapping and direct association analysis in genome-wide association studies.
Genetic epidemiology - 1 Apr 2012
Qin Huaizhen, Zhu Xiaofeng
Abstract excerpt
When dense markers are available, one can interrogate almost every common variant across the genome via imputation and single nucleotide polymorphism (SNP) test, which has become a routine in current genome-wide association studies (GWASs). As a complement, admixture mapping exploits the long-range linkage disequilibrium (LD) generated by admixture between genetically distinct ancestral populations. It is then...
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