Article
Methods for high-density admixture mapping of disease genes.
American journal of human genetics - 1 May 2004
Patterson Nick, Hattangadi Neil, Lane Barton, Lohmueller Kirk E, Hafler David A, Oksenberg Jorge R, Hauser Stephen L, Smith Michael W, O'Brien Stephen J, Altshuler David, Daly Mark J, Reich David
Abstract excerpt
Admixture mapping (also known as "mapping by admixture linkage disequilibrium," or MALD) has been proposed as an efficient approach to localizing disease-causing variants that differ in frequency (because of either drift or selection) between two historically separated populations. Near a disease gene, patient populations descended from the recent mixing of two or more ethnic groups should have an increased...
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