Gene Mapping in Admixed Families: A Cautionary Note on the Interpretation of the Transmission Disequilibrium Test and a Possible Solution.

Abstract excerpt

A family-based study design is commonly used in gene mapping studies of complex human diseases. Most family-based studies use the transmission of alleles to assess evidence of association. It is generally believed that the transmission disequilibrium test (TDT) is robust against spurious association due to population stratification or admixture. While this is true when population stratification is due to discrete...

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