Article
Admixture mapping comes of age.
Annual review of genomics and human genetics - 1 Jan 2010
Winkler Cheryl A, Nelson George W, Smith Michael W
Abstract excerpt
Admixture mapping is based on the hypothesis that differences in disease rates between populations are due in part to frequency differences in disease-causing genetic variants. In admixed populations, these genetic variants occur more often on chromosome segments inherited from the ancestral population with the higher disease variant frequency. A genome scan for disease association requires only enough markers to...
Topics
- Chromosome Mapping
- Computational Biology
- Emigration and Immigration
- Genetic Variation
- Genetics, Population
- Humans
- Models, Genetic
- Racial Groups