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Article

Admixture mapping comes of age.

Annual review of genomics and human genetics - 1 Jan 2010

Winkler Cheryl A, Nelson George W, Smith Michael W

Abstract excerpt

Admixture mapping is based on the hypothesis that differences in disease rates between populations are due in part to frequency differences in disease-causing genetic variants. In admixed populations, these genetic variants occur more often on chromosome segments inherited from the ancestral population with the higher disease variant frequency. A genome scan for disease association requires only enough markers to...

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Identifiers

PMID: 20594047
DOI: 10.1146/annurev-genom-082509-141523
PMCID: PMC7454031

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