Comparison of admixture and association mapping in admixed families.

doi:10.1002/gepi.20239

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Article

Comparison of admixture and association mapping in admixed families.

Genetic epidemiology - 1 Nov 2007

Clarke Geraldine, Whittemore Alice S

Abstract excerpt

The family-based admixture mapping test (AMT) identifies disease-related genes using family data from admixed individuals with the disease of interest (cases). The cases' genotypes at a set of markers are used to infer their DNA ancestry as it varies in blocks along the chromosomes. The test compares the cases' inferred ancestries to those expected from their family histories. Deviation between observed and...

Topics

Chromosomes, Human
Family
Genetic Markers
Genetic Predisposition to Disease
Genetics, Population
Humans
Linkage Disequilibrium
Models, Genetic
Quantitative Trait Loci

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PMID: 17508341
DOI: 10.1002/gepi.20239

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