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Article

Genetic polymorphisms in CYP17, CYP3A4, CYP19A1, SRD5A2, IGF-1, and IGFBP-3 and prostate cancer risk in African-American men: the Flint Men's Health Study.

The Prostate - 15 Feb 2008

Sarma Aruna V, Dunn Rodney L, Lange Leslie A, Ray Anna, Wang Yunfei, Lange Ethan M, Cooney Kathleen A

Abstract excerpt

BACKGROUND: Association studies have examined the significance of several candidate genes based on biological pathways relevant to prostate carcinogenesis, including both the androgen and insulin-like growth factor pathways. Clinical and epidemiologic evidence suggest that androgens, specifically testosterone and dihydrotestosterone (DHT) are important not only in normal prostate growth but in the pathogenesis of...

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Source

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Identifiers

PMID: 18163429
DOI: 10.1002/pros.20696
PMCID: PMC2712831

Genes

IGF1
IGFBP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic polymorphisms in CYP17, CYP3A4, CYP19A1, SRD5A2, IGF-1, and IGFBP-3 and prostate cancer risk in African-American men: the Flint Men's Health Study.PMID 18163429Read ↗

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Fine-mapping IGF1 and prostate cancer risk in African Americans: the multiethnic cohort study.Semantic proximity Read ↗

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Germ-line genetic variation in the key androgen-regulating genes androgen receptor, cytochrome P450, and steroid-5-alpha-reductase type 2 is important for prostate cancer development.Semantic proximity Read ↗

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