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Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks

21 Aug 2008

Abstract excerpt

Chronic stalling of DNA replication forks caused by DNA damage can lead to genomic instability. Cells have evolved lesion bypass pathways such as postreplication repair (PRR) to resolve these arrested forks. In yeast, one branch of PRR involves proliferating cell nuclear antigen (PCNA) polyubiquitination mediated by the Rad5-Ubc13-Mms2 complex that allows bypass of DNA lesion by a template-switching mechanism....

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PMID: 18719106
DOI: 10.1073/pnas.0805685105

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Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forksPMID 18719106Read ↗

Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitinationSemantic proximity Read ↗

Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination.Semantic proximity Read ↗

Human SHPRH is a ubiquitin ligase for Mms2–Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigenSemantic proximity Read ↗

Helicase-Like Transcription Factor HLTF and E3 Ubiquitin Ligase SHPRH Confer DNA Damage Tolerance through Direct Interactions with Proliferating Cell Nuclear Antigen (PCNA).Semantic proximity Read ↗

Rad5 and Its Human Homologs, HLTF and SHPRH, Are Novel Interactors of Mismatch RepairSemantic proximity Read ↗

PCNA Modifications for Regulation of Post-Replication Repair PathwaysSemantic proximity Read ↗

HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: Existence of an alternative E3 ligaseSemantic proximity Read ↗

Spatiotemporal regulation of PCNA ubiquitination in damage tolerance pathwaysSemantic proximity Read ↗

Human ELG1 regulates the level of ubiquitinated proliferating cell nuclear antigen (PCNA) through Its interactions with PCNA and USP1.Semantic proximity Read ↗

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.Semantic proximity Read ↗

Analysis of SHPRH functions in DNA repair and immunoglobulin diversification.Semantic proximity Read ↗

Functional and physical interaction of yeast Mgs1 with PCNA: impact on RAD6-dependent DNA damage tolerance.Semantic proximity Read ↗

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