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Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination

27 Nov 2006

Abstract excerpt

Differential modifications of proliferating cell nuclear antigen (PCNA) determine DNA repair pathways at stalled replication forks. In yeast, PCNA monoubiquitination by the ubiquitin ligase (E3) yRad18 promotes translesion synthesis (TLS), whereas the lysine-63-linked polyubiquitination of PCNA by yRad5 (E3) promotes the error-free mode of bypass. The yRad5-dependent pathway is important to prevent genomic...

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PMID: 17130289
DOI: 10.1083/jcb.200606145

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Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitinationPMID 17130289Read ↗

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