SUMO modification of human XRCC4 regulates its localization and function in DNA double-strand break repair.

doi:10.1128/MCB.26.5.1786-1794.2006

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Article

SUMO modification of human XRCC4 regulates its localization and function in DNA double-strand break repair.

Molecular and cellular biology - 1 Mar 2006

Yurchenko Vyacheslav, Xue Zhu, Sadofsky Moshe J

Abstract excerpt

The nonhomologous end-joining (NHEJ) pathway is responsible for rejoining the majority of double-strand breaks in mammalian cells, including the programmed breaks introduced by V(D)J recombination. The regulation of the enzymatic activities associated with this recombination pathway is still largely unknown. Here we report that human XRCC4 (for X-ray cross-complementation group 4), a protein essential for NHEJ,...

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Identifiers

PMID: 16478998
DOI: 10.1128/MCB.26.5.1786-1794.2006
PMCID: PMC1430232

Genes

XRCC4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.