Article
Molecular dynamics simulations of the Cx26 hemichannel: insights into voltage-dependent loop-gating.
Biophysical journal - 21 Mar 2012
Kwon Taekyung, Roux Benoît, Jo Sunhwan, Klauda Jeffery B, Harris Andrew L, Bargiello Thaddeus A
Abstract excerpt
Loop-gating is one of two voltage-dependent mechanisms that regulate the open probability of connexin channels. The loop-gate permeability barrier is formed by a segment of the first extracellular loop (E1) (the parahelix) and appears to be accompanied by straightening of the bend angle between E1 and the first transmembrane domain (TM1). Here, all-atom molecular dynamics simulations are used to identify and...
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