Cooperative nature of gating transitions in K(+) channels as seen from dynamic importance sampling calculations.

Abstract excerpt

The growing dataset of K(+) channel x-ray structures provides an excellent opportunity to begin a detailed molecular understanding of voltage-dependent gating. These structures, while differing in sequence, represent either a stable open or closed state. However, an understanding of the molecular details of gating will require models for the transitions and experimentally testable predictions for the gating...

Topics

• Amino Acid Sequence
• Computer Simulation
• Crystallography, X-Ray
• Ion Channel Gating
• Models, Molecular
• Molecular Sequence Data
• Mutation
• Potassium Channels
• Protein Structure, Secondary
• Protein Subunits
• Sequence Alignment