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Article

Voltage-dependent conformational changes in connexin channels.

Biochimica et biophysica acta - 1 Aug 2012

Bargiello Thaddeus A, Tang Qingxiu, Oh Seunghoon, Kwon Taekyung

Abstract excerpt

Channels formed by connexins display two distinct types of voltage-dependent gating, termed V(j)- or fast-gating and loop- or slow-gating. Recent studies, using metal bridge formation and chemical cross-linking have identified a region within the channel pore that contributes to the formation of the loop-gate permeability barrier. The conformational changes are remarkably large, reducing the channel pore diameter...

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Identifiers

PMID: 21978595
DOI: 10.1016/j.bbamem.2011.09.019
PMCID: PMC3367129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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