Article
State-dependent network connectivity determines gating in a K+ channel.
Structure (London, England : 1993) - 8 Jul 2014
Bollepalli Murali K, Fowler Philip W, Rapedius Markus, Shang Lijun, Sansom Mark S P, Tucker Stephen J, Baukrowitz Thomas
Abstract excerpt
X-ray crystallography has provided tremendous insight into the different structural states of membrane proteins and, in particular, of ion channels. However, the molecular forces that determine the thermodynamic stability of a particular state are poorly understood. Here we analyze the different X-ray structures of an inwardly rectifying potassium channel (Kir1.1) in relation to functional data we obtained for...
Topics
- Animals
- Crystallography, X-Ray
- Female
- Hydrogen-Ion Concentration
- Ion Channel Gating
- Models, Molecular
- Mutation
- Oocytes
- Patch-Clamp Techniques
- Potassium Channels, Inwardly Rectifying