Article

Free energy and kinetics of cAMP permeation through connexin26 hemichannel with and without voltage

2021-01-19

Abstract excerpt

The connexin family is a diverse group of highly regulated non-β-barrel wide-pore channels permeable to biological signaling molecules. Despite their critical roles in mediating selective molecular signaling in health and disease, the molecular basis of permeation through these pores remains unclear. Here, we report the thermodynamics and kinetics of binding and transport of a second messenger, adenosine-3’,5’-cyc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e8df9b12-0bfa-574b-becc-481ead558787
DOI: 10.1101/2021.01.18.427208

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Free energy and kinetics of cAMP permeation through connexin26 hemichannel with and without voltageDOI 10.1101/2021.01.18.427208Read

Molecular dynamics simulations of the Cx26 hemichannel: insights into voltage-dependent loop-gating.Semantic proximity Read

Computational electrophysiology: the molecular dynamics of ion channel permeation and selectivity in atomistic detail.Semantic proximity Read

A multi-pore model of the blood-brain barrier tight junction strands recapitulates the permeability features of wild-type and mutant claudin-5Semantic proximity Read

A novel voltage clamp/dye uptake assay reveals saturable transport of molecules through CALHM1 and connexin channelsSemantic proximity Read

A negative-hydrated constriction zone is revealed in the active state of the Hv1 channel.Semantic proximity Read

Decrypting the Heat Activation Mechanism of TRPV1 Channel by Molecular Dynamics Simulation.Semantic proximity Read

Voltage-dependent structural models of the human Hv1 proton channel from long-timescale molecular dynamics simulations.Semantic proximity Read

Toward elucidating the heat activation mechanism of the TRPV1 channel gating by molecular dynamics simulation.Semantic proximity Read

The Impact of Pathogenic and Artificial Mutations on Claudin-5 Selectivity from Molecular Dynamics SimulationsSemantic proximity Read

Structural and Energetic Basis of Ca2+-Selective Permeation in the TRPV5 Channel.Semantic proximity Read

A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential.Semantic proximity Read

Model-based Evaluation of Connexin Hemichannel PermeabilitySemantic proximity Read