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Article

Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening.

Proceedings of the National Academy of Sciences of the United States of America - 6 Aug 2013

Zaydman Mark A, Silva Jonathan R, Delaloye Kelli, Li Yang, Liang Hongwu, Larsson H Peter, Shi Jingyi, Cui Jianmin

Abstract excerpt

Voltage-gated ion channels generate dynamic ionic currents that are vital to the physiological functions of many tissues. These proteins contain separate voltage-sensing domains, which detect changes in transmembrane voltage, and pore domains, which conduct ions. Coupling of voltage sensing and pore opening is critical to the channel function and has been modeled as a protein-protein interaction between the two...

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Identifiers

PMID: 23861489
DOI: 10.1073/pnas.1305167110
PMCID: PMC3740903

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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