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Article

Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis.

Cell research - 1 Aug 2012

Liu Liren, Yin Yan, Li Yuewei, Prevedel Lisa, Lacy Elizabeth H, Ma Liang, Zhou Pengbo

Abstract excerpt

Mutations of the CUL4B ubiquitin ligase gene are causally linked to syndromic X-linked mental retardation (XLMR). However, the pathogenic role of CUL4B mutations in neuronal and developmental defects is not understood. We have generated mice with targeted disruption of Cul4b, and observed embryonic lethality with pronounced growth inhibition and increased apoptosis in extra-embryonic tissues. Cul4b, but not its...

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Identifiers

PMID: 22453236
DOI: 10.1038/cr.2012.48
PMCID: PMC3411166

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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