Article
CUL4B mutations impair human cortical neurogenesis through PP2A-dependent inhibition of AKT and ERK.
Cell death & disease - 8 Feb 2024
Ma Yanyan, Liu Xiaolin, Zhou Min, Sun Wenjie, Jiang Baichun, Liu Qiao, Wang Molin, Zou Yongxin, Liu Qiji, Gong Yaoqin, Sun Gongping
Abstract excerpt
Mutation in CUL4B gene is one of the most common causes for X-linked intellectual disability (XLID). CUL4B is the scaffold protein in CUL4B-RING ubiquitin ligase (CRL4B) complex. While the roles of CUL4B in cancer progression and some developmental processes like adipogenesis, osteogenesis, and spermatogenesis have been studied, the mechanisms underlying the neurological disorders in patients with CUL4B mutations...
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