Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RBX1/ROC1 disruption results in early embryonic lethality due to proliferation failure, partially rescued by simultaneous loss of p27.

Proceedings of the National Academy of Sciences of the United States of America - 14 Apr 2009

Tan Mingjia, Davis Shannon W, Saunders Thomas L, Zhu Yuan, Sun Yi

Abstract excerpt

RBX1 (RING box protein-1) or ROC1 (regulator of cullins-1) is the RING component of SCF (Skp1, Cullins, F-box proteins) E3 ubiquitin ligases, which regulate diverse cellular processes by targeting various substrates for degradation. However, the in vivo physiological function of RBX1 remains uncharacterized. Here, we show that a gene trap disruption of mouse Rbx1 causes embryonic lethality at embryonic day...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carrier Proteins
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p27

Share to Embryo Loss

Share to Embryo, Mammalian

Share to Embryonic Stem Cells

Share to Gene Expression Regulation, Developmental

Share to Genome

Source

Open in PubMed Open full text

Identifiers

PMID: 19325126
DOI: 10.1073/pnas.0812425106
PMCID: PMC2669381

Genes

RBX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RBX1/ROC1 disruption results in early embryonic lethality due to proliferation failure, partially rescued by simultaneous loss of p27.PMID 19325126Read ↗

Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligasesSemantic proximity Read ↗

Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E.Semantic proximity Read ↗

Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice.Semantic proximity Read ↗

Caenorhabditis elegans RBX1 is essential for meiosis, mitotic chromosomal condensation and segregation, and cytokinesis.Semantic proximity Read ↗

Multiple functions of Jab1 are required for early embryonic development and growth potential in mice.Semantic proximity Read ↗

Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis.Semantic proximity Read ↗

Fbxw7 in cell cycle exit and stem cell maintenance: Insight from gene-targeted miceSemantic proximity Read ↗

The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis.Semantic proximity Read ↗

ROC1/RBX1 E3 Ubiquitin Ligase Silencing Suppresses Tumor Cell Growth via Sequential Induction of G2-M Arrest, Apoptosis, and SenescenceSemantic proximity Read ↗

Small RING Finger Proteins RBX1 and RBX2 of SCF E3 Ubiquitin Ligases: The Role in Cancer and as Cancer TargetsSemantic proximity Read ↗

Rbx1 Cullin-Ring ligase E3 and Ube2m neddylation E2 differentially governs the fitness of Treg cellsSemantic proximity Read ↗

Paradoxical instability-activity relationship defines a novel regulatory pathway for retinoblastoma proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.